张彦丰

  发布时间: 2015-03-16   信息员:

张彦丰,男,博士,福建农林大学特聘教授,金山学者,博士研究生导师。 2009年在美国密歇根州立大学博士毕业,先后于美国太平洋西北国家实验室和德克萨斯大学健康科学中心从事博士后研究,并且有美国生物制药公司担任资深科学家的科研经历。主要利用X-射线晶体学,从事致病菌中危害人类健康的毒素蛋白质和决定毒素生成的蛋白质结构和功能的研究。还利用ELISA蛋白质芯片技术,从事危害人类健康的多种相关毒素检测的研究。曾经参与完成美国NIH课题3项。目前担任美国先进科学学会(American Association for theAdvancement of Science)会员,美国结晶学会(American Crystallographic Association)会员,美国晶体生长协会(American Association for Crystal Growth)会员,Journal of plant pathology and microbiology执行编委,以及Journal of Analytical and Bioanalytical Techniques等9个杂志编委等学术兼职。

受教育经历
1) 2004/01-2009/12,美国密歇根州立大学,遗传学,博士
2) 2007/03-2009/08,美国密歇根州立大学,应用统计学,硕士
3) 2000/09-2003/03,齐齐哈尔大学,生命科学学院,硕士
4) 1996/09-2000/07,辽宁大学,生命科学学院,学士

研究工作经历
1) 2014/03-至今,福建农林大学,生命科学学院,特聘教授、博士生导师。
2) 2013/05-2014/03,美国赛托万斯生物制药公司,资深科学家 (Senior Scientist)
3) 2012/05-2013/05,美国德克萨斯大学健康科学中心,博士后
4) 2010/04-2012/04,美国太平洋西北国家实验室,博士后

发表学术论文
1. Y Zhang, Y Zheng, L Qin, S Wang, GW Buchko, RM Garavito. Structural characterization of a β-hydroxyacid dehydrogenase from Geobactersulfurreducens and Geobactermetallireducens with succinic semialdehyde reductase activity. Biochimie, 2014, 104:61-69. (PDB ID: 3PDU and 3PEF).
2. KL Jenko*, Y Zhang*, YKostenko, J Lou, JD Marks, SM Varnum. Development of a toxin ELISA microarray assay for the sensitive and simultaneous detection of ten biodefense toxins. The Analyst, 2014,in press. (*共同第一作者)
3. Y Zhang, AGardberg, TE Edwards, B Sankaran, H Robinson,SM Varnum, GW Buchko. Structural insights into the functional role of the Hcn sub-domain of the receptor binding domain of botulinum neurotoxin mosaic serotype C/D. Biochimie, 2013,95(7): 1379-1385. (PDB ID: 4F83).
4. H Jin*, Y Zhang*, GW Buchko, SM Varnum, H Robinson, TC Squier, PE Long. Structure determination and functional analysis of a chromate reductase from Gluconacetobacterhansenii.PLoS ONE, 2012, 7(8): e42432. (*共同第一作者, PDB ID: 3S2Y)
5. Y Zhang, J Lou, KL Jenko, JD Marks, SM Varnum. Simultaneous and sensitive detection of six serotypes of botulinum neurotoxin using enzyme-linked immunosorbent assay-based protein antibody microarrays. Analytical Biochemistry, 2012, 430: 185-192.
6. Y Zhang, SM Varnum. The receptor binding domain of botulinum neurotoxin serotype C binds phosphoinositides. Biochimie, 2012, 94: 920-923.
7. Y Zhang, X Gao, RM Garavito. Biochemical characterization of human dynamin-like protein 1. The Journal of Biochemistry, 2011, 150 (6): 615-625.
8. Y Zhang, X Gao, RM Garavito. Structural analysis of the intracellular domain of (pro)renin receptor fused to maltose-binding protein. Biochemical and Biophysical Research Communications, 2011, 407: 674-679. (PDB ID: 3LBS and 3LC8)
9. Y Zhang, GW Buchko, L Qin, H Robinson, SM Varnum.Crystal structure of the receptor binding domain of botulinum neurotoxin mosaic serotype C/D reveals potential roles of lysines 1118 and 1136 in membrane interactions. Biochemical and Biophysical Research Communications, 2011, 404: 407-412. (PDB ID: 3PME)
10. Y Zhang, GW Buchko, L Qin, H Robinson, SM Varnum. Structural analysis of the receptor binding domain of botulinum neurotoxin serotype D. Biochemical and Biophysical Research Communications,2010, 401: 498-503. (PDB ID: 3OGG)
11. Y Zhang, X Gao, Y Zheng, RM Garavito. Identification of succinic semialdehyde reductases from Geobacter: expression, purification, preliminary functional and crystallographic analysis.ActaBiochimicaetBiophysicaSinica, 2011, 43 (12): 996-1002.
12. Y Zhang, X Gao. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of L-lactate dehydrogenase and its mutant H171C from Bacillus subtilis.ActaCrystallographica Section F: Structural Biology and Crystallization Communications, 2011, F68: 63-65.
13. Y Zhang, X Gao,GW Buchko, L Qin, H Robinson, SM Varnum. High-level expression, purification, crystallization, and preliminary X-ray crystallographic studies of the receptor binding domain of botulinum neurotoxin serotype D. ActaCrystallographica Section F: Structural Biology and Crystallization Communications, 2010, F66: 1610-1613.
14. Y Zheng, S Anderson, Y Zhang, RM Garavito. The structure of sucrose synthase-1 from Arabidopsis thaliana and its functional implications. Journal of Biological Chemistry, 2011, 286 (41): 36108-36118.
15. C Yang, J Fan, Z Zhuang, Y Fang, Y Zhang,S Wang. The role of NAD(+)-dependent isocitrate dehydrogenase 3 subunit α in AFB1 induced liver lesion. Toxicology Letter, 2014, 224: 371-379.
16. Buchko GW, Abendroth J, Robinson H, Zhang Y, Hewitt SN, Edwards TE, Van Voorhis WC, Myler PJ.Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia. Journal of Structural and Functional Genomics, 2013, 14(2): 47-57.
17. Khaleel, J., Gong, C., Zhang, Y., Tan, R., Squier, T. and Jin, H. Mutations in FMN binding pocket diminish chromate reduction rates for Gh-ChrR isolated from Gluconacetobacterhansenii. Natural Science, 2013, 5: 20-24.
18. R Wang, S Fang, D Wu, J Lian, J Fan, Y Zhang, S Wang, W Lin. Screening of a scFv antibody that can effectively neutralize the cytotoxicity of Vibrio parahaemolytucsthermolabilehemolysin. Applied Environmental Microbiology, 2012, 78:4967-4975.